Tunicate-Inspired Photoactivatable Proteinic Nanobombs for Tumor-Adhesive Multimodal Therapy
- 주제(키워드) bioinorganic chemistry , multimodal anticancer therapy , NIR-responsive nanotherapeutics , protein-based photothermal agents , vanadium-doping effect
- 주제(기타) Engineering, Biomedical
- 주제(기타) Nanoscience & Nanotechnology
- 주제(기타) Materials Science, Biomaterials
- 설명문(일반) [Jeong, Yeonsu; Il Joo, Kye; Cha, Hyung Joon] Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 37673, South Korea; [Jo, Yun Kee; Kim, Mou Seung] Kyungpook Natl Univ, Sch Convergence, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; [Jo, Yun Kee] Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41566, South Korea; [Il Joo, Kye] Ewha Womans Univ, Div Chem Engn & Mat Sci, Seoul 03760, South Korea
- 관리정보기술 faculty
- 등재 SCOPUS
- 발행기관 WILEY
- 발행년도 2021
- URI http://www.dcollection.net/handler/ewha/000000191093
- 본문언어 영어
- Published As https://doi.org/10.1002/adhm.202101212
- PubMed https://pubmed.ncbi.nlm.nih.gov/34626527
초록/요약
Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol-vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered "bomb-like" multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer.
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