초록/요약

Dual transition-metal catalysis has been introduced as a robust tool to synthesize a diverse range of organic compounds that cannot to be accessed by traditional single-metal catalysis. In this context, we have recently developed cooperative Rh(II)/Pd(0) dual catalytic systems that have been utilized for the preparation of heterocyclic compounds through the reaction between Rh(II)-carbenoid and pi-allyl Pd(II)-complex intermediates in either synergistic or tandem relay catalysis. In synergistic Rh(II)/Pd(0) dual catalysis, the two reactive intermediates are generated simultaneously, which then undergo formal [6+3] dipolar cycloaddition to afford medium-sized heterocyclic compounds. On the other hand, tandem relay dual catalysis can be enabled through judicious choice of reaction parameters, which proceed through the insertion of Rh(II)-carbenoid into O-H or C-H bonds, followed by Pd(0)-catalyzed allylation to provide allylated benzo-fused cyclic compounds or chiral beta-lactam derivatives. 1 Introduction 2 Synergistic Dual Rh(II)/Pd(0)-Catalyzed Dipolar [6+3]-Cycloaddition for the Synthesis of 1,4-Oxazonines 3 Tandem Relay Dual Rh(II)/Pd(0) Catalysis for the Synthesis of 2-Aminoindanones 4 Asymmetric Tandem Relay Dual Rh(II)/Pd(0) Catalysis for the Synthesis of alpha-Quaternary Chiral beta-Lactams 5 Tandem Relay Dual Rh(II)/Pd(0) Catalysis for the Synthesis of alpha-Quaternary Indolinones and Benzofuranones 6 Conclusion