Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy
- 주제(키워드) upconversion , localized surface plasmon resonance , titanium dioxide , photosensitizer , phototherapy
- 주제(기타) Nanoscience & Nanotechnology
- 주제(기타) Materials Science, Multidisciplinary
- 설명문(일반) [Yu, Subin; Yuan, Hong; Kim, Minju; Mota, Filipe Marques; Kim, Dong Ha] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Jang, Dohyub; Kim, Sehoon] Korea Inst Sci & Technol, Ctr Theragnosis, Seoul 02792, South Korea; [Jang, Dohyub] Korea Univ, Dept Biomicrosyst Technol, Seoul 136701, South Korea; [Huang, Wen-Tse; Liu, Ru-Shi] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191140
- 본문언어 영어
- Published As https://doi.org/10.1021/acsami.1c21949
- PubMed https://pubmed.ncbi.nlm.nih.gov/34855366
초록/요약
Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO(2)@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO(2)) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO(2) and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO(2), generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO(2) (77.3%) and UCNP@aTiO(2) (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO(2)@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agent, providing a valuable addition to light-triggered cancer treatments in deep tissue.
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