Copper(II)-MOF Containing Glutarate and 4,4 '-Azopyridine and Its Antifungal Activity
- 주제(키워드) <p>4 , 4 & PRIME , -azopyridine</p> , glutaric acid , metal-organic frameworks (MOFs) , X-ray crystallography , antifungal activity
- 주제(기타) Chemistry, Multidisciplinary
- 주제(기타) Engineering, Multidisciplinary
- 주제(기타) Materials Science, Multidisciplinary
- 주제(기타) Physics, Applied
- 설명문(일반) [Yang, Sohyeon; Kim, Sungjin; Kim, Youngmee] Ewha Womans Univ, NanoBio Energy Mat Ctr, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Veerana, Mayura; Yu, Nannan; Ketya, Wirinthip; Park, Gyungsoon] Kwangwoon Univ, Plasma Biosci Res Ctr, Dept Elect & Biol Phys, Seoul 01897, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191143
- 본문언어 영어
- Published As https://doi.org/10.3390/app12010260
초록/요약
Antifungal activities of MOFs (metal organic frameworks) have been demonstrated in studies, and improvement in efficiency of fungal inactivation is a critical issue in the application of MOFs. In this study, we employed 4,4 & PRIME;-azopyridine (AZPY) in the construction of MOF to improve its antifungal activity. Three-dimensional (3D) copper metal organic framework containing glutarate (Glu) and AZPY (Cu(AZPY)-MOF) was synthesized by a solvothermal reaction. Glutarates bridge Cu-2 dinuclear units to form two-dimensional (2D) layers, and these layers are connected by AZPY to form a 3D framework. When spores of two fungi, Candida albicans and Aspergillus niger, were treated with Cu(AZPY)-MOF for one day, number of CFU (colony forming unit) was continuously reduced over treated MOF concentrations, and maximum 2.3 and 2.5 log(10)CFU reductions (approximately 99% reduction) were observed in C. albicans and A. niger, respectively. Small amounts of Cu-II ions and AZPY released from Cu(AZPY)-MOF were not critical for fungal inactivation. Our results indicate that the level of antifungal activity of Cu(AZPY)-MOF is greater than that of Cu-MOF without AZPY constructed in our previous study, and intercalation of AZPY is able to improve the antifungal activity of Cu(AZPY)-MOF.
more