Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp.
- 주제(키워드) Saccharomonospora sp , marine natural products , antibacterial activity
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Kim, Sohee; Han, Sang-Ah; Hong, Ahreum] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea; [Le, Tu Cam] Ton Duc Thang Univ, Adv Inst Mat Sci, Lab Adv Mat Chem, Ho Chi Minh City 700000, Vietnam; [Le, Tu Cam] Ton Duc Thang Univ, Fac Sci Appl, Ho Chi Minh City 700000, Vietnam; [Hillman, Prima F.; Cha, Sun-Shin; Lee, Jihye; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Hong, Ahreum; Lee, Jihye] REDONE Seoul, Labs Marine New Drugs, Seoul, South Korea; [Hwang, Sunghoon; Du, Young Eun; Oh, Dong-Chan] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; [Kim, Hiyoung] Konkuk Univ, Dept Biomed Sci & Engn, Seoul 05029, South Korea; [Fenical, William] Univ Calif San Diego, Ctr Marine Biotechnol & Biomed, Scripps Inst Oceanog, La Jolla, CA 92093 USA
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191145
- 본문언어 영어
- Published As https://doi.org/10.3390/md20010035
- PubMed https://pubmed.ncbi.nlm.nih.gov/35049890
초록/요약
Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ-490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7-chloro-4(1H)-quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 mu g/mL and 64 mu g/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti-quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.
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