Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics
- 주제(키워드) ultrasound , upconversion , near-infrared , microbubble , nanohybrid
- 주제(기타) Chemistry, Multidisciplinary
- 주제(기타) Chemistry, Physical
- 주제(기타) Nanoscience & Nanotechnology
- 주제(기타) Materials Science, Multidisciplinary
- 설명문(일반) [Jeong, Keunsoo; Kim, Dojin; Kim, Hyun Jun; Lee, Yong-Deok; Yoo, Jounghyun; Jang, Dohyub; Lee, Seokyung; Park, Hyeonjong; Kim, Youngsun; Kim, Sehoon] Korea Inst Sci & Technol, Ctr Theragnosis, Seoul 02792, South Korea; [Kim, Hyun Jun; Park, Hyeonjong; Kim, Jungahn] Kyung Hee Univ, Dept Chem, Seoul 02447, South Korea; [Lee, Yong-Deok; Ahn, Dong June; Bang, Joona] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea; [Jang, Dohyub; Ahn, Dong June] Korea Univ, Dept Biomicrosyst Technol, Seoul 02841, South Korea; [Jang, Dohyub; Kim, Dong Ha] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Singh, Ajay; Prasad, Paras N.] SUNY Buffalo, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA; [Singh, Ajay; Prasad, Paras N.] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA; [Ahn, Dong June; Kim, Sehoon] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191147
- 본문언어 영어
- Published As https://doi.org/10.1021/acsnano.1c07898
- PubMed https://pubmed.ncbi.nlm.nih.gov/34605648
초록/요약
Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics.
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