Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617
- 주제(키워드) Streptomyces sp , deoxyvasicinone , marine natural products , anti-melanogenic effect
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Lee, Se-eun; Kim, Min-ju] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea; [Hillman, Prima F.; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & NanoSci, Seoul 03760, South Korea; [Oh, Dong-Chan] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; [Fenical, William] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, San Diego, CA 92093 USA; [Lim, Kyung-Min] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191175
- 본문언어 영어
- Published As https://doi.org/10.3390/md20020155
- PubMed https://pubmed.ncbi.nlm.nih.gov/35200684
초록/요약
The tricyclic quinazoline alkaloid deoxyvasicinone (DOV, 1) was isolated from a marine-derived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by alpha-melanocyte-stimulating hormone (alpha-MSH). In addition, microscopic images of the cells showed that deoxyvasicinone attenuated melanocyte activation. Although, deoxyvasicinone did not directly inhibit tyrosinase (TYR) enzymatic activity, real-time PCR showed that it inhibited the mRNA expression of TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). In the artificial 3D pigmented skin model Melanoderm(TM), deoxyvasicinone brightened the skin significantly, as confirmed by histological examination. In conclusion, this study demonstrated that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect through downregulation of melanogenic enzymes.
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