A Nanostructured Phthalocyanine/Albumin Supramolecular Assembly for Fluorescence Turn-On Imaging and Photodynamic Immunotherapy
- 주제(키워드) photodynamic immunotherapy , turn-on fluorescence , supramolecular assembly , phototheranostic , phthalocyanine
- 주제(기타) Chemistry, Multidisciplinary
- 주제(기타) Chemistry, Physical
- 주제(기타) Nanoscience & Nanotechnology
- 주제(기타) Materials Science, Multidisciplinary
- 설명문(일반) [Wang, Rui; Kwon, Nahyun; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Kim, Kyu-Hwan; Yoo, Jiyoon; Jeon, Yun-Hui; Shin, Suk-kyung; Han, Seung Seok; Lee, Dong-Sup] Seoul Natl Univ, Wide River Inst Immunol, Coll Med, Dept Biomed Sci, Seoul 03080, South Korea; [Li, Xingshu] Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, State Key Lab Photocatalysis Energy & Environm, Coll Chem, Fuzhou 350108, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191177
- 본문언어 영어
- Published As https://doi.org/10.1021/acsnano.1c10565
- PubMed https://pubmed.ncbi.nlm.nih.gov/35089696
초록/요약
Smart phototheranostic nanomaterials are of significant interest for high-quality imaging and targeted therapy in the precision medicine field. Herein, a nanoscale photosensitizer (NanoPcM) is constructed through the self-assembly of morpholine-substituted silicon phthalocyanine (PcM) and albumin. NanoPcM displays a turn-on fluorescence depending on the acid-induced abolition of the photoinduced electron transfer effect (change in molecular structure) and disassembly of the nanostructure (change in supramolecular structure), which enables low-background and tumor-targeted fluorescence imaging. In addition, its efficient type I photoreaction endows NanoPcM with a superior immunogenic photodynamic therapy (PDT) effect against solid tumors. The combination of NanoPcM-based PDT and alpha PD-I -based immunotherapy can efficiently inhibit tumor growth, reduce spontaneous lung metastasis, and trigger abscopal effects. This study should provide a perspective for the future design of nanomaterials as promising phototheranostics for cancer imaging and therapy.
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