Phthalocyanine-Assembled "One-For-Two" Nanoparticles for Combined Photodynamic-Photothermal Therapy of Multidrug-Resistant Bacteria
- 주제(키워드) photodynamic therapy , photothermal therapy , multidrug-resistant bacteria , phthalocyanine self-assembly , one-for-two
- 주제(기타) Nanoscience & Nanotechnology
- 주제(기타) Materials Science, Multidisciplinary
- 설명문(일반) [Wang, Rui; Kim, Dayeh; Yang, Mengyao; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Li, Xingshu] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000191179
- 본문언어 영어
- Published As https://doi.org/10.1021/acsami.1c21891
- PubMed https://pubmed.ncbi.nlm.nih.gov/35112836
초록/요약
The treatment of diseases caused by drug-resistant bacterial infections urgently requires new types of broad-spectrum antimicrobial materials. Herein, we introduce a supramolecular self-assembly, NanoPcN, which realizes the combination of type I photodynamic activity and photothermal effects by modifying zinc(II) phthalocyanine with a 3-(dimethylamino) phenoxy group. Antibacterial experiments demonstrate that this "one-for-two" property endows NanoPcN with excellent antimicrobial efficacy, not only against Gram-positive and Gram-negative bacteria but also against multidrug-resistant bacteria. An ultralow concentration of NanoPcN (50 nM) almost completely inhibited the growth of methicillin-resistant Staphylococcus aureus upon 655 nm laser irradiation (0.5 W/cm(2)) for 2 min, and the antibacterial effect was significantly stronger than that of the known photosensitizers methylene blue and tetraphenylporphyrin tetrasulfonic acid. Thus, the construction of "one-for-two" materials through a simple molecular structure modification paves a feasible way for the development of effective broad-spectrum antibacterial agents.
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