The association of pancreatic cancer incidence with smoking status and smoking amount in Korean men
- 주제(키워드) WORDS , Smoking , Pancreatic cancer , Smoking cessation
- 주제(기타) Public, Environmental & Occupational Health
- 설명문(일반) [Nam, Do Jin; Yang, Eun Hye; Lee, Hyo Choon; Shin, Soon Su] Kyung Hee Univ, Dept Occupat, Med Ctr, Seoul, South Korea; [Oh, Chang-Mo; Kim, Min-Ho] Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea; [Ha, Eunhee] Ewha Womans Univ, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea; [Hwang, Woo Yeon] Kyung Hee Univ Hosp, Dept Obstet & Gynecol, Seoul, South Korea; [You, Ann Hee] Kyung Hee Univ Hosp, Dept Anesthesiol & Pain Med, K, Seoul, South Korea; [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, 23 Kyungheedae Ro, Seoul 02447, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 KOREAN SOC EPIDEMIOLOGY
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000193052
- 본문언어 영어
- Published As https://doi.org/10.4178/epih.e2022040
- PubMed https://pubmed.ncbi.nlm.nih.gov/35468271
초록/요약
OBJECTIVES: Our study examined the dose-response relationship between smoking amounts (pack-years) and the risk of developing pancreatic cancer in Korean men. METHODS: Of 125,743 participants who underwent medical health checkups in 2009, 121,408 were included in the final analysis and observed for the development of pancreatic cancer. We evaluated the associations between smoking amounts and incident pancreatic cancer in 4 groups classified by pack-year amounts. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of incident pancreatic cancer by comparing groups 2 (< 20 packyear smokers), 3 (20-<= 40 pack-year smokers), and 4 (> 40 pack-year smokers) with group 1 (never smokers). RESULTS: During 527,974.5 person-years of follow-up, 245 incident cases of pancreatic cancer developed between 2009 and 2013. The multivariate-adjusted HRs (95% CIs) for incident pancreatic cancer in groups 2, 3, and 4 were 1.05 (0.76 to 1.45), 1.28 (0.91 to 1.80), and 1.57 (1.00 to 2.46), respectively (p for trend= 0.025). The HR (95% CI) of former smokers showed a dose-response relationship in the unadjusted model, but did not show a statistically significant association in the multivariate-adjusted model. The HR (95% CI) of current smokers showed a dose-response relationship in both the unadjusted (p for trend= 0.020) and multivariate-adjusted models (p for trend= 0.050). CONCLUSIONS: The risk of developing pancreatic cancer was higher in current smokers status than in former smokers among Korean men, indicating that smoking cessation may have a protective effect.
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