Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate
- 주제(키워드) Complex coacervate , Dual drug-in-bioadhesive , Full-thickness skin grafting , Mussel adhesive protein , Wound healing process
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2022
- URI http://www.dcollection.net/handler/ewha/000000193240
- 본문언어 영어
- Published As https://doi.org/10.1016/j.cej.2022.137272
초록/요약
Conventional skin grafting procedures such as suturing and stapling are accompanied by pathologic scarring with functional and psychological sequelae; severe scars need a prolonged recovery period, increasing the chance of wound infections or graft contraction. The present study develops a novel bioadhesive delivering dual drugs to minimize scar formation and accelerate wound healing during full-thickness skin grafting. The bioadhesive is prepared via coacervation of a mussel protein and shows high adhesive strength in both porcine skin and in vivo rodent models; furthermore, it sustainably releases dual drugs (allantoin and epithelial growth factor) to enhance re-epithelialization and collagen deposition while simultaneously reducing scar formation. The proposed dual-drug-in-bioadhesive coacervate may ideally meet the requirements of the wound healing process and is a promising candidate for sutureless full-thickness skin grafting. © 2022 Elsevier B.V.
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