Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step
- 등재 SCIE, SCOPUS
- 발행기관 Royal Society of Chemistry
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000193264
- 본문언어 영어
- Published As https://doi.org/10.1039/d2qo00747a
초록/요약
The stereocontrolled total synthesis of the antitumor natural product thioamycolamide A has been accomplished in 14 longest linear steps and an overall yield of 19.1%. The central feature of our convergent route to this family of novel macrocyclic natural products is the preparation of the β-alkylthio amide subunit through an auxiliary-controlled, diastereoselective sulfa-Michael addition. © 2022 The Royal Society of Chemistry
more