The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days
- 주제(키워드) Benzo(a)pyrene , Gastrointestinal Cancer , Oral Intake , Low -Dose , p53 , MUC
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Zheng, Zhi; Jiang, Linjuan] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan, Peoples R China; [Park, Jung Kuk] Ghent Univ Global Campus, Dept Environm Technol Food Technol & Mol Technol, Incheon, South Korea; [Kwon, Oh Wook; Park, Byoung Hee] Raphagen Co Ltd, Seoul, South Korea; [Ahn, Sung Hoon] Kangwon Natl Univ, Dept Pharm, Coll Pharm, Chunchon, South Korea; [Kwon, Young Joo] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul, South Korea; [Zhu, Shaohui] Xinxiang Med Coll, Affiliated Hosp 1, Xinxiang, Henan, Peoples R China; [Park, Byoung Hee] HealingBio Co Ltd, Cheongju, South Korea; [Park, Byoung Hee] Korea Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN ACAD MEDICAL SCIENCES
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000194490
- 본문언어 영어
- Published As https://doi.org/10.3346/jkms.2022.37.e235
- PubMed https://pubmed.ncbi.nlm.nih.gov/35916047
초록/요약
Background: Benzo(a)pyrene (BaP) is a carcinogenic compound in contaminated foodstuffs. The effect of oral intake of the environmental carcinogen BaP under low doses and frequent exposure on a digestive system has not been thoroughly verified. Methods: In this regard, this study was conducted to prove the toxicity effects of BaP on the stomach and colon tissue after exposure to C57BL/6 mouse (3 and 6 jig/kg) following daily oral administration for 60 days. This study investigated acute gastric mucosal injury, severe gastric edema, cell infiltration, and mononuclear cells, multifocal cells, and tumoral inflammatory cells. Results: The results of ELISA showed that the expression of serum interleukin (IL)-6 and tumor necrosis factor-alpha in the BaP exposure group were significantly increased, and a high level of DNA adduct distribution in their stomach and colon. Moreover, this study has confirmed the expression of early carcinogenesis markers: nuclear factor (NF)-Kappa B, p53, IL-6, superoxide dismutase 1 (SOD1), mucin (MUC1 and MUC2), and beta-catenin in the stomach and colon, and showed that there was a significant increase in IL-6, NF-Kappa B, SOD1, beta-catenin, and MUC1 (P < 0.05). At the same time, there was a significant decrease in MUC2 and p53 (P < 0.05). Thus, even in low doses, oral intake of BaP can induce DNA damage, increasing the potential risk of gastrointestinal cancer. Conclusion: This study will provide a scientific basis for researching environmental contaminated food and intestinal health following daily oral administration of BaP.
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