5G Electromagnetic Radiation Attenuates Skin Melanogenesis In Vitro by Suppressing ROS Generation
- 주제(키워드) non-ionizing radiation , electromagnetic waves , 5G , skin pigmentation , melanogenesis
- 주제(기타) Biochemistry & Molecular Biology
- 주제(기타) Chemistry, Medicinal
- 주제(기타) Food Science & Technology
- 설명문(일반) [Kim, Kyuri; Lim, Kyung-Min] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Lee, Young Seung; Choi, Hyung-Do] Elect & Telecommun Res Inst, Radio & Satellite Res Div, Daejeon 34129, South Korea; [Kim, Nam] Chungbuk Natl Univ, Dept Comp & Commun Engn, Cheongju 28644, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000194493
- 본문언어 영어
- Published As https://doi.org/10.3390/antiox11081449
- PubMed https://pubmed.ncbi.nlm.nih.gov/35892650
초록/요약
Recently, the impacts of 5G electromagnetic radiation (EMR) with 28 GHz on human health have been attracting public attention with the advent of 5G wireless communication. Here, we report that 5G (28 GHz) EMR can attenuate the skin pigmentation in murine melanoma cells (B16F10) and a 3D pigmented human epidermis model (Melanoderm (TM)). B16 cells were exposed to 5G (28 GHz) with or without alpha-MSH for 4 h per day. Interestingly, 5G attenuated alpha-MSH-induced melanin synthesis. Fontana-Masson staining confirmed that the dendritic formation of alpha-MSH stimulated B16 cells was diminished by 5G exposure. To confirm the anti-melanogenic effect of 5G EMR, MelanoDerm (TM) was irradiated with 5G at a power intensity of 10 W/m(2) for 4 h a day for 16 days and melanin distribution was detected with Fontana-Masson staining, which supported the anti-melanogenic effect of 5G EMR. Consistently, 5G EMR suppressed alpha-MSH induced upregulation of melanogenic enzymes; tyrosinase, TRP-1, and TRP-2. Of note, 5G EMR attenuated ROS production stimulated by alpha-MSH and H2O2, suggesting that 5G EMR may dissipate ROS generation, which is pivotal for the melanin synthesis. Collectively, we demonstrated that 5G EMR can attenuate skin pigmentation by attenuating ROS generation.
more