Impact of a multidomain lifestyle intervention on regional spontaneous brain activity
- 주제(키워드) regional homogeneity , dementia , prevention , lifestyle , intervention , cognition , SUPERBRAIN , brain activity
- 주제(기타) Geriatrics & Gerontology
- 주제(기타) Neurosciences
- 설명문(일반) [Moon, So Young; Lee, Sun Min] Ajou Univ, Sch Med, Dept Neurol, Suwon, South Korea; [Shin, Seong A.; Lee, Jong-Min] Hanyang Univ, Dept Biomed Engn, Seoul, South Korea; [Jeong, Jee Hyang; Park, Hee Kyung] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; [Hong, Chang Hyung] Ajou Univ, Sch Med, Dept Psychiat, Suwon, South Korea; [Park, Yoo Kyoung] Kyung Hee Univ, Grad Sch East West Med Nutr, Dept Med Nutr, Suwon, South Korea; [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Seongnam Si, South Korea; [Song, Hong-Sun] Korea Inst Sports Sci, Dept Sports Sci, Seoul, South Korea; [Choi, Muncheong] Shinhan Univ, Dept Sports & Hlth Sci, Uijeongbu Si, South Korea; [Chun, Buong-O] Myongi Univ, Coll Arts & Phys Educ, Grad Sch Phys Educ, Yongin, South Korea; [Choi, Seong Hye] Inha Univ, Sch Med, Dept Neurol, Incheon, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000194611
- 본문언어 영어
- Published As https://doi.org/10.3389/fnagi.2022.926077
- PubMed https://pubmed.ncbi.nlm.nih.gov/35966769
초록/요약
In the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of multidomain lifestyle intervention on regional homogeneity (ReHo) in resting-state functional brain magnetic resonance imaging (MRI) data. Of 152 participants aged 60-79 years without dementia assigned to either facility-based multidomain intervention (FMI), home-based MI, or controls, we analyzed 56 scanned MRIs at baseline and 24 weeks. ReHo values from regions with significant longitudinal changes were compared between the intervention and control groups and their correlations with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) or serum brain-derived neurotrophic factor (BDNF) were evaluated. ReHo values in the left medial orbitofrontal gyrus and right superior parietal lobule were increased [p = 0.021, correlated positively with serum BDNF changes (r = 0.504, p = 0.047)] and decreased [p = 0.021, correlated negatively with changes in the total (r = -0.509, p = 0.044) and attention (r = -0.562, p = 0.023). RBANS], respectively, in the participants assigned to the FMI group than those of the controls. Our results suggest that facility-based group preventive strategies may have cognitive benefits through neuroplastic changes in functional processing circuits in the brain areas which play a crucial role in the adaptive learning and internally directed cognition.
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