Controllable Nitric Oxide Storage and Release in Cu-BTC: Crystallographic Insights and Bioactivity
- 주제(키워드) nitric oxide , drug delivery , MOFs , antibacterial activity
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 설명문(일반) [Lee, Do Nam; Lee, Su Jung] Kwangwoon Univ, Ingenium Coll Liberal Arts Chem, Seoul 01897, South Korea; [Kim, Yeong Rim; Shin, Jae Ho] Kwangwoon Univ, Dept Chem, Seoul 01897, South Korea; [Yang, Sohyeon; Kim, Youngmee; Kim, Sung-Jin] Ewha Womans Univ, Nanobioenergy Mat Ctr, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Ngoc Minh Tran; Yoo, Hyojong] Hanyang Univ, Dept Mat Sci & Chem Engn, Ansan 15588, South Korea; [Ngoc Minh Tran] Univ Sci, Hue Univ, Dept Chem, Hue City 530000, Vietnam; [Park, Bong Joo] Kwangwoon Univ, Dept Elect & Biol Phys, Seoul 01897, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000202943
- 본문언어 영어
- Published As https://doi.org/10.3390/ijms23169098
- PubMed https://pubmed.ncbi.nlm.nih.gov/36012363
초록/요약
Crystalline metal-organic frameworks (MOFs) are extensively used in areas such as gas storage and small-molecule drug delivery. Although Cu-BTC (1, MOF-199, BTC: benzene-1,3,5-tricarboxylate) has versatile applications, its NO storage and release characteristics are not amenable to therapeutic usage. In this work, micro-sized Cu-BTC was prepared solvothermally and then processed by ball-milling to prepare nano-sized Cu-BTC (2). The NO storage and release properties of the micro- and nano-sized Cu-BTC MOFs were morphology dependent. Control of the hydration degree and morphology of the NO delivery vehicle improved the NO release characteristics significantly. In particular, the nano-sized NO-loaded Cu-BTC (NO subset of nano-Cu-BTC, 4) released NO at 1.81 mu mol center dot mg(-1) in 1.2 h in PBS, which meets the requirements for clinical usage. The solid-state structural formula of NO subset of Cu-BTC was successfully determined to be [CuC6H2O5]center dot(NO)(0.167) through single-crystal X-ray diffraction, suggesting no structural changes in Cu-BTC upon the intercalation of 0.167 equivalents of NO within the pores of Cu-BTC after NO loading. The structure of Cu-BTC was also stably maintained after NO release. NO subset of Cu-BTC exhibited significant antibacterial activity against six bacterial strains, including Gram-negative and positive bacteria. NO subset of Cu-BTC could be utilized as a hybrid NO donor to explore the synergistic effects of the known antibacterial properties of Cu-BTC.
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