Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp
- 주제(기타) Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy
- 설명문(일반) [Kim, Sohee] Ewha Womans Univ, Coll Pharm, Grad Sch Ind Pharmaceut Sci, Seoul 03760, South Korea; [Kim, Sohee; Lee, Jihye] REDONE SEOUL, Labs Marine New Drugs, Seoul 08594, South Korea; [Hillman, Prima F.; Lee, Ji Young; Lee, Juri; Lee, Jihye; Cha, Sun-Shin; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Oh, Dong-Chan] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 08826, South Korea; [Fenical, William] Univ Calif San Diego, Ctr Marine Biotechnol & Biomed, Scripps Inst Oceanog, La Jolla, CA 92093 USA
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGERNATURE
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000202965
- 본문언어 영어
- Published As https://doi.org/10.1038/s41429-022-00562-2
- PubMed https://pubmed.ncbi.nlm.nih.gov/36109669
초록/요약
HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1-3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 mu g ml(-1), respectively.
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