Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Liu, Xiaosheng; Zeng, Shuang; Zhang, Ming; Kafuti, Yves S.; Shangguan, Pingping; Yu, Yichu; Chen, Qixian; Wang, Jingyun; Li, Haidong] Dalian Univ Technol, Sch Bioengn, 2 Linggong Rd, Dalian 116024, Peoples R China; [Jiang, Maojun; Wang, Jingyun; Peng, Xiaojun; Li, Haidong] Dalian Univ Technol, Frontiers Sci Ctr Smart Mat Oriented Chem Engn, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China; [Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000202973
- 본문언어 영어
- Published As https://doi.org/10.1039/d2cc04112j
- PubMed https://pubmed.ncbi.nlm.nih.gov/36135099
초록/요약
We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.
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