Impact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study
- 주제(키워드) Cortical thickness , Dementia , Prevention , Lifestyle , Intervention
- 주제(기타) Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
- 설명문(일반) [Moon, So Young; Lee, Sun Min] Ajou Univ, Dept Neurol, Sch Med, Suwon, South Korea; [Kim, Sohui] Hanyang Univ, Dept Elect Engn, Seoul, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea; [Hong, Chang Hyung] Ajou Univ, Dept Psychiat, Sch Med, Suwon, South Korea; [Park, Yoo Kyoung] Kyung Hee Univ, Grad Sch East West Med Nutr, Dept Med Nutr, Suwon, South Korea; [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Seongnam, South Korea; [Song, Hong-Sun; Chun, Buong-O] Korea Inst Sports Sci, Dept Sports Sci, Seoul, South Korea; [Park, Hee Kyung; Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, 260 Gonghang daero, Seoul 07804, South Korea; [Choi, Muncheong] Kookmin Univ, Dept Phys Educ, Seoul, South Korea; [Choi, Muncheong] Exercowork, Seoul, South Korea; [Lee, Jong-Min] Hanyang Univ, Dept Biomed Engn, Sanhak kisulkwan Bldg 319 222 Wangsipri ro, Seoul 133791, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, hybrid
- 발행기관 SPRINGER
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000202995
- 본문언어 영어
- Published As https://doi.org/10.1007/s13311-022-01276-x
- PubMed https://pubmed.ncbi.nlm.nih.gov/35915368
초록/요약
In the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based multidomain intervention (FMI) and home-based MI (HMI) on cortical thickness, brain volume, and the serum brain-derived neurotrophic factor (BDNF). Totally, 152 participants, aged 60-79 years without dementia but with >= 1 modifiable dementia risk factor, were randomly assigned to the FMI, HMI, or control groups. Among them, 55 participants (20 FMI, 19 HMI, and 16 controls) underwent brain MRI at baseline and 24 weeks. We compared changes in global/regional mean cortical thickness at the region-of-interest (ROI) between the intervention and control groups. The changes in the total cortical gray matter volume and global mean cortical thickness were compared using analysis of covariance with age, sex, and education as covariates. ComBat site harmonization was applied for cortical thickness values across the scanners. ROI-based analysis was controlled for multiple comparisons, with a false discovery rate threshold of p < 0.05. Serum BDNF levels were significantly higher in the FMI group than in the control group (p = 0.029). Compared with the control group, the mean global cortical thickness increased in the FMI group (0.033 +/- 0.070 vs. - 0.003 +/- 0.040, p = 0.013); particularly, cortical thickness of the bilateral frontotemporal lobes, cingulate gyri, and insula increased. The increase in cortical thickness and serum BDNF in the FMI group suggests that group preventive strategies at the facility may be beneficial through structural neuroplastic changes in brain areas, which facilitates learning and neurotrophic factors.
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