The association between changes in proteinuria and the risk of cerebral infarction in the Korean population
- 주제(키워드) Proteinuria , Urine dipstick test , Cerebral infarction
- 주제(기타) Endocrinology & Metabolism
- 설명문(일반) [Park, Sung Keun; Jung, Ju Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Sch Med, Seoul, South Korea; [Oh, Chang-Mo] Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea; [Ha, Eunhee] Ewha Womans Univ, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea; [Shin, Soon Su; Lee, Hyo Choon] Kyung Hee Univ Hosp, Dept Occupat & Environm Med, Seoul, South Korea; [Hwang, Woo Yeon] Kyung Hee Univ Hosp, Dept Obstet & Gynecol, Seoul, South Korea; [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, Seoul, South Korea; [Kim, Min -Ho] Kyung Hee Univ, Grad Sch, Dept Prevent Med, Seoul, South Korea; [Kim, Min -Ho] Ewha Womans Univ, Informatizat Dept, Seoul Hosp, Seoul, South Korea; [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, 23 Kyungheedae Ro, Seoul 02447, South Korea
- 등재 SCIE, SCOPUS
- OA유형 hybrid
- 발행기관 ELSEVIER IRELAND LTD
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203026
- 본문언어 영어
- Published As https://doi.org/10.1016/j.diabres.2022.110090
- PubMed https://pubmed.ncbi.nlm.nih.gov/36122864
초록/요약
Background: Proteinuria is a risk factor for cerebral infarction. It is known that proteinuria can change over time. However, published data is scarce for the association between changes in proteinuria and the risk of cerebral infarction.Method: Study participants were 276,861 Koreans who were assessed for urine dipstick proteinuria both in 2003-2004 and 2007-2008. They were categorized into four groups by changes in proteinuria over 4 years (negative: negative-* negative, resolved: proteinuria >= 1+-* negative, incident: negative-* proteinuria >= 1+, persistent: proteinuria >= 1+-* proteinuria >= 1 + ). We used multivariate adjusted Cox-proportional hazard model in calculating the adjusted hazard ratios (HR) and 95% confidence interval (CI) for cerebral infarction until 2013 according to changes in proteinuria. Result: Adjusted HR and 95% CI for cerebral infarction significantly increased in order of persistent, incident, and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.166 [1.009-1.347], incident: 1.345 [1.188-1.522], and persistent: 1.443 [1.089-1.912]). In gender subgroup analysis, men showed the more clear association between changes in proteinuria and the risk of cerebral infarction (negative: reference, resolved: 1.284 [1.057-1.560], incident: 1.351 [1.149-1.589], and persistent: 1.428 [1.014-2.012]).Conclusion: All types of proteinuria changes were associated with the increased risk of cerebral infarction, even in participants with once manifested but vanishing proteinuria.
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