Multiple primary cancers in men with sporadic or familial prostate cancer: Its clinical implications
- 주제(키워드) Prostate cancer , Familial , Multiple primary cancer , Clinical characteristics
- 주제(기타) Oncology; Urology & Nephrology
- 설명문(일반) [Kim, Myong] Ewha Womans Univ, Dept Urol, Seoul Hosp, Seoul, South Korea; [Sung, Joohon] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth, Genome & Hlth Big Data Lab, Seoul, South Korea; [Kim, Jung Kwon; Lee, Hakmin; Oh, Jong Jin; Lee, Sangchul; Hong, Sung Kyu; Byun, Seok-Soo] Seoul Natl Univ, Dept Urol, Bundang Hosp, Seongnam, South Korea; [Byun, Seok-Soo] Seoul Natl Univ, Dept Med Device Dev, Collage Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE INC
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203027
- 본문언어 영어
- Published As https://doi.org/10.1016/j.urolonc.2022.07.016
- PubMed https://pubmed.ncbi.nlm.nih.gov/36167773
초록/요약
Objective: To evaluate the risk of concordant cancers in patients with prostate cancer (CaP) and examine whether this risk differed according to family history of CaP. Materials and methods: We examined 1,102 patients with CaP , having prospectively acquired pedigrees, and analyzed information regarding multiple primary cancers. The prevalence of concordant cancers was assessed with respect to the family history of CaP . First -degree familial CaP was defined as a positive history of CaP in first-degree relatives (parents, siblings, and offspring). Odds ratios for each concordant cancer in men with first-degree familial CaP were estimated. Clinical characteristics were compared between men with and without concordant cancers. Results: The prevalence of multiple primary cancers in sporadic PCa was 12.0%, similar to that of first-degree familial CaP (13.5%, P = 0.698). Gastrointestinal cancer was the most common concordant cancer (3.6%), followed by colorectal (2.9%), lung (1.5%), urothelial (1.3%), kidney (1.1%), and other cancers. Colorectal cancer was more frequent in first-degree familial CaP than in sporadic disease (6.8 vs. 2.7%, P = 0.045). However, the rates of other concordant cancers were similar between the 2 groups (P range, 0.242-0.963). Compared with sporadic disease, the age-adjusted odds ratio for concordant colorectal cancer in first-degree familial CaP was 2.930 (95% confidence interval, 1.082-7.929). Patients with concordant colorectal cancer had fewer (2.8 vs. 3.9 cores, P = 0.041) and a lower percentage of (23.5 vs. 33.1%, P = 0.030) positive biopsy cores than CaP only patients. Conclusions: A family history of CaP was significantly associated with a risk of concordant colorectal cancer. These findings imply that some CaP shares a genetic pathogenesis with colorectal cancer. (c) 2022 Published by Elsevier Inc.
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