The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)
- 주제(키워드) Brain metastasis , Breast neoplasms , Overall survival , Pattern of care study
- 주제(기타) Oncology
- 설명문(일반) [Kim, Jae Sik; Shin, Kyung Hwan; Kim, In Ah] Seoul Natl Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea; [Kim, Kyubo; Jung, Wonguen; Kim, Kyung Su] Ewha Womans Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea; [Im, Seock-Ah; Kim, Jee Hyun] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Kim, Hee-Jun] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Kim, Yong Bae; Chang, Jee Suk] Yonsei Univ, Yonsei Canc Ctr, Coll Med, Dept Radiat Oncol, Seoul, South Korea; [Choi, Doo Ho] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiat Oncol, Seoul, South Korea; [Park, Yeon Hee] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Internal Med, Seoul, South Korea; [Kim, Dae Yong; Kim, Tae Hyun] Natl Canc Ctr, Proton Therapy Ctr, Goyang, South Korea; [Choi, Byung Ock; Lee, Sea-Won] Catholic Univ Korea, Seoul St Marys Hosp, Dept Radiat Oncol, Seoul, South Korea; [Lee, Sea-Won] Catholic Univ Korea, Eunpyeong St Marys Hosp, Dept Radiat Oncol, Seoul, South Korea; [Kim, Suzy] Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Radiat Oncol, Seoul, South Korea; [Kwon, Jeanny] Chungnam Natl Univ, Coll Med, Dept Radiat Oncol, Daejeon, South Korea; [Kang, Ki Mun] Gyeongsang Natl Univ, Sch Med, Dept Radiat Oncol, Chang Won, South Korea; [Kang, Ki Mun] Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea; [Chung, Woong-Ki] Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Radiat Oncol, Hwasun, South Korea; [Kim, Kyung Su] Dongnam Inst Radiol & Med Sci, Dept Radiat Oncol, Busan, South Korea; [Nam, Ji Ho] Pusan Natl Univ, Yangsan Pusan Natl Univ Hosp, Sch Med, Dept Radiat Oncol, Yangsan, South Korea; [Yoon, Won Sup] Korea Univ, Ansan Hosp, Coll Med, Dept Radiat Oncol, Asan, South Korea; [Kim, Jin Hee] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Radiat Oncol, Daegu, South Korea; [Cha, Jihye] Yonsei Univ, Wonju Severance Christian Hosp, Wonju Coll Med, Dept Radiat Oncol, Wonju, South Korea; [Oh, Yoon Kyeong] Chosun Univ, Med Sch, Dept Radiat Oncol, Gwangju, South Korea; [Kim, In Ah] Seoul Natl Univ, Bundang Hosp, Dept Radiat Oncol, 82 Gumi Ro 173beon Gil, Seongnam 13620, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN CANCER ASSOCIATION
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203038
- 본문언어 영어
- Published As https://doi.org/10.4143/crt.2021.1083
- PubMed https://pubmed.ncbi.nlm.nih.gov/34990524
초록/요약
Purpose We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea. Materials and Methods We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.5 months. We categorized the patients into three groups according to the year when BM was initially diagnosed (group I [2005-2008], 98 patients; group II [2009-2011], 200 patients; and group III [2012-2014], 302 patients). Results Over time, the median age at BM diagnosis increased by 2.2 years (group I, 49.0 years; group II, 48.3 years; and group III, 51.2 years; p=0.008). The percentage of patients with extracranial metastasis was 73.5%, 83.5%, and 86.4% for group I, II, and III, respectively (p=0.011). The time interval between BC and BM was prolonged in patients with stage III primary BC (median, 2.4 to 3 years; p=0.029). As an initial brain-directed treatment, whole-brain radiotherapy alone decreased from 80.0% in 2005 to 41.1% in 2014. Meanwhile, stereotactic radiosurgery or fractionated stereotactic radiotherapy alone increased from 13.3% to 34.7% during the same period (p=0.005). The median OS for group I, II, and III was 15.6, 17.9, and 15.0 months, respectively, with no statistical significance. Conclusion The manifestations of BM from BC and the pattern of care have changed from 2005 to 2014 in Korea. However, the OS has remained relatively unchanged over the 10 years.
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