Long-Term Survival and Kidney Function in Pediatric Patients Following Liver Transplantation: A 15-Year Retrospective Cohort Study
- 주제(키워드) long-term survival , kidney function , pediatric patients , liver transplantation
- 주제(기타) Pediatrics
- 설명문(일반) [Son, Rin; Rhie, Sandy Jeong] Ewha Womans Univ, Grad Sch Converging Clin & Publ Hlth, Seoul 03760, South Korea; [Son, Rin; Suh, Sung Yun; Cho, Yoon Sook] Seoul Natl Univ Hosp, Dept Pharm, 101 Daehak Ro, Seoul 03080, South Korea; [Suh, Sung Yun; Rhie, Sandy Jeong] Ewha Womans Univ, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Rhie, Sandy Jeong] Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203054
- 본문언어 영어
- Published As https://doi.org/10.3390/children9101544
- PubMed https://pubmed.ncbi.nlm.nih.gov/36291480
초록/요약
Long-term preservation of kidney function after liver transplantation (LT) has not been well studied. We thus evaluated the rates of kidney function preservation and long-term survival after pediatric LT. We also investigated the risk factors associated with the progression of chronic kidney disease (CKD). We conducted a retrospective study of 184 pediatric patients who had undergone LT from 2003 to 2018 at a university hospital. We collected demographics, primary indications for LT, liver disease scores, renal function test results, immunosuppressive drug prescriptions, and diagnosis of post-LT complications. The 15-year survival rate was 90.8%. Furthermore, the rate of kidney function preservation at 14 years post-LT in patients at high risk of renal disease was 79.3%, and that in those with less risk of kidney diseases was 96.0%. Arterial hypertension was an independent risk factor associated with CKD progression. However, when arterial hypertension was excluded, the use of cyclosporine and liver disease with renal involvement were risk factors for CKD progression. We found that kidney function after pediatric LT was well preserved. We encourage the early detection of underlying kidney involvement, routine monitoring of renal function for high-risk patients, active control of hypertension, and appropriate immunosuppressive regimens for pediatric patients with LT.
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