Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
- 주제(키워드) family history , colorectal cancer , age
- 주제(기타) Health Care Sciences & Services; Medicine, General & Internal
- 설명문(일반) [Jung, Yoon Suk] Sungkyunkwan Univ, Sch Med, Div Gastroenterol, Dept Internal Med,Kangbuk Samsung Hosp, Seoul 03181, South Korea; [Song, Huiyeon] Hanyang Univ, Grad Sch Publ Hlth, Dept Epidemiol & Biostat, Seoul 04763, South Korea; [Tran, Mai Thi Xuan; Park, Boyoung] Hanyang Univ, Coll Med, Dept Prevent Med, Seoul 04763, South Korea; [Moon, Chang Mo] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul 07985, South Korea; [Moon, Chang Mo] Ewha Womans Univ, Coll Med, Inflammat Canc Microenvironm Res Ctr, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 MDPI
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203055
- 본문언어 영어
- Published As https://doi.org/10.3390/jpm12101566
- PubMed https://pubmed.ncbi.nlm.nih.gov/36294706
초록/요약
Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged >= 40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 +/- 0.8 years, 0.43% of the 292,467 participants with family history and 0.28% of the 1,169,868 participants without family history developed CRC. Participants with a family history in any FDR, parents only, and siblings only had a higher risk of CRC than those without family history; adjusted hazard ratios (HRs) were 1.53, 1.46, and 1.61, respectively. Participants with a family history comprising both parents and siblings had an even higher risk of CRC than those without a family history (HR, 2.34). The HRs for CRC in the 40-49, 50-59, 60-69, 70-79, and >= 80 age groups with family history were 1.72, 1.74, 1.50, 1.30, and 0.78, respectively (p < 0.001). A family history of CRC in any FDR and both parents and siblings was associated with an approximately 1.5- and 2.3-fold increased risk of CRC. The effect of family history was relatively greater in the younger than the older age group.
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