Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent dementia
- 주제(키워드) cognitive impairment , biomarkers , quantitative electroencephalography , dementia , multidomain intervention
- 주제(기타) Geriatrics & Gerontology; Neurosciences
- 설명문(일반) [Park, Hee Kyung; Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; [Park, Hee Kyung] UCL, Dept Mental Hlth Care Older People, Div Psychiat, London, England; [Choi, Seong Hye] Inha Univ, Sch Med, Dept Neurol, Incheon, South Korea; [Kim, SeonMyeong; Park, Ukeob; Kang, Seung Wan] iMediSync Inc, Seoul, South Korea; [Kang, Seung Wan] Seoul Natl Univ, Coll Nursing, Data Ctr Korean EEG, Seoul, South Korea; [Moon, So Young; Lee, Sun Min] Ajou Univ, Sch Med, Dept Neurol, Suwon, South Korea; [Hong, Chang Hyung] Ajou Univ Sch Med, Dept Psychiat, Suwon, South Korea; [Song, Hong-Sun] Korea Inst Sports Sci, Dept Sports Sci, Seoul, South Korea; [Chun, Buong-O] Myongji Univ, Coll Arts & Phys Educ, Grad Sch Phys Educ, Seoul, South Korea; [Choi, Muncheong] Shinhan Univ, Dept Sports & Hlth Sci, Uijeongbu Si, South Korea; [Park, Kyung Won] Dong A Univ, Coll Med, Dept Neurol, Pusan, South Korea; [Kim, Byeong C.; Cho, Soo Hyun] Chonnam Natl Univ, Med Sch & Hosp, Dept Neurol, Gwangju, South Korea; [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Seongnam, South Korea; [Park, Yoo Kyoung] Kyung Hee Univ, Grad Sch East West Med Nutr, Dept Med Nutr, Yongin, South Korea; [Park, Yoo Kyoung] Kyung Hee Univ, Grad Sch East West Med Nutr, Dept Food Innovat & Hlth, Yongin, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203068
- 본문언어 영어
- Published As https://doi.org/10.3389/fnagi.2022.892590
- PubMed https://pubmed.ncbi.nlm.nih.gov/36313025
초록/요약
Quantitative electroencephalography (QEEG) has proven useful in predicting the response to various treatments, but, until now, no study has investigated changes in functional connectivity using QEEG following a lifestyle intervention program. We aimed to investigate neurophysiological changes in QEEG after a 24-week multidomain lifestyle intervention program in the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN). Participants without dementia and with at least one modifiable dementia risk factor, aged 60-79 years, were randomly assigned to the facility-based multidomain intervention (FMI) (n = 51), the home-based multidomain intervention (HMI) (n = 51), and the control group (n = 50). The analysis of this study included data from 44, 49, and 34 participants who underwent EEG at baseline and at the end of the study in the FMI, HMI, and control groups, respectively. The spectrum power and power ratio of EEG were calculated. Source cortical current density and functional connectivity were estimated by standardized low-resolution brain electromagnetic tomography. Participants who received the intervention showed increases in the power of the beta1 and beta3 bands and in the imaginary part of coherence of the alpha1 band compared to the control group. Decreases in the characteristic path lengths of the alpha1 band in the right supramarginal gyrus and right rostral middle frontal cortex were observed in those who received the intervention. This study showed positive biological changes, including increased functional connectivity and higher global efficiency in QEEG after a multidomain lifestyle intervention.
more