Mixed ligand octahedral Zn(II) complex of N boolean AND N boolean AND O donor tridentate Schiff base ligand and N boolean AND N donor bidentate bipyridine ligand: Synthesis, characterization, biological activity and cytotoxicity
- 주제(키워드) antimicrobial activities , biomolecular interaction , cytotoxicity studies , mixed ligand Zn(II) complex , tridentate NNO Schiff base
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Vijayan, Thamilarasan; Nasirian, Azam; Kim, Jinheung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul, South Korea; [Pugazhenthi, Mani] AVVM Sri Pushpam Coll, Dept Chem, Thanjavur, Tamil Nadu, India; [Pugazhenthi, Mani] Bharathidasan Univ, Tiruchirappalli, Tamil Nadu, India; [Kasi, Gopinath] Southwest Univ, Chongqing Key Lab Adv Mat & Technol Clean Energie, Chongqing, Peoples R China; [Jayamani, Arumugam] Manav Rachna Univ, Sch Appl Sci, Dept Chem, Faridabad 121004, Haryana, India
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203071
- 본문언어 영어
- Published As https://doi.org/10.1002/bkcs.12618
초록/요약
Tridentate NNO donor Schiff base ligand and its mixed ligand zinc(II) complex were synthesized stoichiometrically and characterized by electronic, infrared, mass spectral techniques and elemental analysis. To understand the DNA binding ability, the complex was investigated by various analytical and spectroscopic techniques in presence of calf thymus DNA (CT-DNA). The binding studies showed that the zinc complex interacts with DNA by groove binding mode with intrinsic binding strength of 2.11 x 10(5) M-1 and with bovine serum albumin the complex showed dynamic quenching attributed for changes in the secondary structure of BSA with efficient interaction. The MCF-7 cell line studies of the zinc(II) complex with 90.8 mu M IC50 value revealed that the complex is effective for the breast cancer cell line and has a potential as anticancer drug. Furthermore, the tridentate ligand and its mixed ligand zinc complex were screened for antibacterial and antifungal activities, which showed better antimicrobial activity for complex.
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