Enhanced delivery of the phototherapeutic nanoparticles via hepatocyte overload
- 주제(키워드) Hepatocyte overload , Indocyanine green , Methylene blue , Phototheraputic nanoparticles , Solutol
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203270
- 본문언어 영어
- Published As https://doi.org/10.1016/j.colsurfb.2022.112959
- PubMed https://pubmed.ncbi.nlm.nih.gov/36343478
초록/요약
Phototherapeutic nanoparticles (NPs) were prepared with methylene blue (MB), indocyanine green (ICG), and Solutol through self-assembly. Generation of reactive oxygen species and elevation of temperature were observed that verify the photodynamic/photothermal effects of the NPs. Morphology and size distribution of the NPs were examined by transmittance electron microscopy and dynamic light scattering. The biodistribution of the NPs and their antitumor efficacy were examined using tumor-bearing mice to understand the phototherapeutic effect of the NPs on tumors. To enhance targetability with enhanced therapeutic efficacy, empty NPs (Solutol nanoparticles without MB and ICG) at different concentrations were injected along with the phototherapeutic NPs. Enhanced delivery of the phototherapeutic NPs at the tumor site was examined based on hepatocyte overload. © 2022 Elsevier B.V.
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