Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non- Alcoholic Fatty Liver Disease in Mice
- 주제(키워드) Fenofibrate , Non-alcoholic fatty liver disease , Peroxisomal disorders , PPAR alpha
- 주제(기타) Endocrinology & Metabolism
- 설명문(일반) [Jiang, Songling; Uddin, Md Jamal; Yu, Xiaoying; Piao, Lingjuan; Dorotea, Debra; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Oh, Goo Taeg] Ewha Womans Univ, Dept Life Sci, Seoul, South Korea; [Ha, Hunjoo] Ewha Womans Univ Coll Pharm, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN DIABETES ASSOC
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203880
- 본문언어 영어
- Published As https://doi.org/10.4093/dmj.2021.0274
초록/요약
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and dia-betes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism of lipid and reactive oxygen spe-cies. The present study examined the role of peroxisomes in high-fat diet (HFD)-induced NAFLD using fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist.Methods: Eight-week-old male C57BL/6J mice were fed either a normal diet or HFD for 12 weeks, and fenofibrate (50 mg/kg/day) was orally administered along with the initiation of HFD.Results: HFD-induced liver injury as measured by increased alanine aminotransferase, inflammation, oxidative stress, and lipid accumulation was effectively prevented by fenofibrate. Fenofibrate significantly increased the expression of peroxisomal genes and proteins involved in peroxisomal biogenesis and function. HFD-induced attenuation of peroxisomal fatty acid oxidation was also significantly restored by fenofibrate, demonstrating the functional significance of peroxisomal fatty acid oxidation. In Ppara deficient mice, fenofibrate failed to maintain peroxisomal biogenesis and function in HFD-induced liver injury.Conclusion: The present data highlight the importance of PPAR alpha-mediated peroxisomal fitness in the protective effect of fenofi-brate against NAFLD.
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