Brownian ratchet for directional nanoparticle transport by repetitive stretch-relaxation of DNA
- 주제(기타) Physics, Fluids & Plasmas; Physics, Mathematical
- 설명문(일반) [Oh, Inrok] ILG Chem Ltd, LG Sci Pk, Seoul 07796, South Korea; [Song, Jeongeun; Hyun, Hye Ree; Kim, Jun Soo] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Lee, Sang Hak] Pusan Natl Univ, Dept Chem, Busan 46241, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER PHYSICAL SOC
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203887
- 본문언어 영어
- Published As https://doi.org/10.1103/PhysRevE.106.054117
초록/요약
Brownian motion subject to a periodic and asymmetric potential can be biased by external, nonequilibrium fluctuations, leading to directional movement of Brownian particles. Sequence-dependent flexibility variation along double-stranded DNA has been proposed as a tool to develop periodic and asymmetric potentials for DNA binding of cationic nanoparticles with sizes below tens of nanometers. Here, we propose that repetitive stretching and relaxation of a long, double-stranded DNA molecule with periodic flexibility gradient can induce nonequilibrium fluctuations that tune the amplitude of asymmetric potentials for DNA-nanoparticle binding to result in directional transport of nanometer-sized particles along DNA. Realization of the proposed Brownian ratchet was proven by Brownian dynamics simulations of coarse-grained models of a single, long DNA molecule with flexibility variation and a cationic nanoparticle.
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