Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01)
- 주제(키워드) locally advanced head and neck squamous cell carcinoma , gender , clinical outcome
- 주제(기타) Oncology
- 설명문(일반) [Lee, Yun-Gyoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Internal Med, Seoul 03181, South Korea; [Kang, Eun Joo] Korea Univ, Guro Hosp, Dept Internal Med, Seoul 08308, South Korea; [Keam, Bhumsuk] Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; [Choi, Jin-Hyuk] Ajou Univ Hosp, Dept Hematol Oncol, Suwon 16499, South Korea; [Kim, Jin-Soo] SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul 07061, South Korea; [Park, Keon Uk] Keimyung Univ, Dongsan Med Ctr, Dept Hematooncol, Daegu 42601, South Korea; [Lee, Kyoung Eun] Ewha Womens Univ Hosp, Dept Hematol & Oncol, Seoul 07985, South Korea; [Lee, Keun-Wook] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam 13620, South Korea; [Kim, Min Kyoung] Yeungnam Univ, Med Ctr, Dept Hematol Oncol, Daegu 42415, South Korea; [Ahn, Hee Kyung] Gachon Univ, Gil Med Ctr, Dept Internal Med, Incheon 21565, South Korea; [Shin, Seong Hoon] Kosin Univ, Gospel Hosp, Dept Internal Med, Pusan 49267, South Korea; [Kim, Hye Ryun] Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Internal Med, Seoul 03722, South Korea; [Kim, Sung-Bae] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 05505, South Korea; [Kim, Hyo Jung] Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Anyang 14068, South Korea; [Yun, Hwan Jung] Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon 35015, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000203910
- 본문언어 영어
- Published As https://doi.org/10.3390/cancers15020471
초록/요약
Simple Summary Though women account for approximately 30% of newly diagnosed head and neck cancer, women have comprised only 17% of the study population in landmark clinical trials so far. Caution is therefore required when applying research outcomes directly to women in actual clinical practice. We hypothesized that there is no difference in treatment strategies and their effect on survival in treating locally advanced head and neck squamous cell carcinoma (LA-HNSCC) in the real world. We aimed to compare multidisciplinary treatment modalities and their outcomes by sex in 445 patients with stage III to IVB LA-HNSCC. In our overall and propensity-matched cohorts, there were no significant differences in the treatment strategy or OS by gender. In the present era, in which a multidisciplinary approach is emphasized, we conclude that there is no apparent sex-based disparity in the treatment modalities and outcomes in treating LA-HNSCC. We aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSCC. To minimize the observed confounding, propensity score matching was utilized. The study included 445 patients; 385 (86.5%) were men and 60 (13.5%) were women. In terms of age, smoking habits, drinking habits, and primary tumor locations, there was a significant imbalance in sex before the matching. Propensity score matching yielded 60 patient pairs, with no statistical difference between the sexes in terms of their characteristics. As for the treatment strategies, there were no significant differences between the sexes before (p = 0.260) and after (p = 0.585) the propensity score matching. When comparing the survival probabilities between the sexes, OS was not significantly different in the overall (HR 1.02; 95% CI 0.59-1.76; p = 0.938) and propensity-score-matched population (HR 1.46; 95% CI 0.68-3.17; p = 0.331). These results suggest that there was no difference in prognosis by gender in the treatment modalities and outcomes of LA-HNSCC in real-world practice.
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