Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Kafuti, Yves S. S.; Wang, Jingyun; Peng, Xiaojun; Li, Haidong] Dalian Univ Technol, Frontiers Sci Ctr Smart Mat Oriented Chem Engn, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China; [Kafuti, Yves S. S.; Zeng, Shuang; Liu, Xiaosheng; Qian, Ming; Chen, Qixian; Wang, Jingyun; Li, Haidong] Dalian Univ Technol, Sch Bioengn, 2 Linggong Rd, Dalian 116024, Liaoning, Peoples R China; [Han, Jingjing; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Han, Jingjing] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Mattenstr 26, CH-4058 Basel, Switzerland
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000204235
- 본문언어 영어
- Published As https://doi.org/10.1039/d2cc06645a
초록/요약
A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H2S levels in solution and in living systems (cells and zebrafish).
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