Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery
- 주제(기타) Materials Science, Biomaterials
- 설명문(일반) [Shin, Kyounghee; Lee, Boryeong; Ryu, Hyunsun; Kim, Jin Woong] Sungkyunkwan Univ, Sch Chem Engn, Suwon 16149, South Korea; [Lee, Kun Bong] Sungkyunkwan Univ, Interdisciplinary Program Biocosmet, Suwon 16419, South Korea; [Hwang, Jee-Hyun; Lim, Kyung-Min] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Noh, Minjoo; Lee, Jun Bae] Cosmax R&I Ctr, Innovat Lab, Seongnam 13486, South Korea; [Nam, Yoon Sung] Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Daejeon 34141, South Korea
- 등재 SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000204239
- 본문언어 영어
- Published As https://doi.org/10.1039/d2tb02734h
초록/요약
This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
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