The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srI kappa Bs) in Chronic Post-Ischemia Pain (CPIP) Models
- 주제(키워드) exosomes , exosome loaded with super-repressor I kappa B , chronic post-ischemic pain model , complex regional pain syndrome (CRPS) , allodynia , NF kappa B , inflammation , neuropathic pain
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Chae, Ji Seon; Kim, Youn Jin; Oh, Hye-Won; Lee, Hyun Jung; Kim, Won-joong] Ewha Womans Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 07804, South Korea; [Park, Hyunju; Lee, Yoonjin; Choi, Youn-Hee] Ewha Womans Univ, Coll Med, Inflammat Canc Microenvironm Res Ctr, Dept Physiol, Seoul 07804, South Korea; [Ahn, So-Hee; Han, Eun-Chong; Choi, Chulhee] ILIAS Biol Inc, ILIAS Innovat Ctr, Daejeon 34014, South Korea; [Ahn, Eun-Jin] Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 06974, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000204276
- 본문언어 영어
- Published As https://doi.org/10.3390/pharmaceutics15020553
초록/요약
Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain that causes significant impairment of daily activities and functioning. Nuclear factor kappa B (NF kappa B) is thought to play an important role in the mechanism of CRPS. Recently, exosomes loaded with super-repressor inhibitory kappa B (Exo-srI kappa B, I kappa B; inhibitor of NF kappa B) have been shown to have potential anti-inflammatory effects in various inflammatory disease models. We investigated the therapeutic effect of Exo-srI kappa B on a rodent model with chronic post-ischemia pain (CPIP), a representative animal model of Type I CRPS. After intraperitoneal injection of a vehicle, Exo-srI kappa B, and pregabalin, the paw withdrawal threshold (PWT) was evaluated up to 48 h. Administration of Exo-srI kappa B increased PWT compared to the vehicle and pregabalin, and the relative densities of p-I kappa B and I kappa B showed significant changes compared to the vehicle 24 h after Exo-srI kappa B injection. The levels of several cytokines and chemokines were reduced by the administration of Exo-srI kappa B in mice with CPIP. In conclusion, our results showed more specifically the role of NF kappa B in the pathogenesis of CRPS and provided a theoretical background for novel treatment options for CRPS.
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