Tschimganidine reduces lipid accumulation through AMPK activation and alleviates high-fat diet-induced metabolic diseases
- 주제(키워드) AMPK , Metabolic diseases , Natural product , Tschimganidine
- 주제(기타) Biochemistry & Molecular Biology
- 설명문(일반) [Hwang, Min-Seon; Baek, Jung-Hwan; Song, Jun-Kyu; Chun, Kyung-Hee] Yonsei Univ, Coll Med, Dept Biochem & Mol Biol, Seoul 03722, South Korea; [Hwang, Min-Seon; Baek, Jung-Hwan; Chun, Kyung-Hee] Yonsei Univ, Coll Med, Inst Genet Sci, Seoul 03722, South Korea; [Hwang, Min-Seon; Baek, Jung-Hwan; Chun, Kyung-Hee] Yonsei Univ, Coll Med, Grad Sch Med Sci, Brain Korea 21 Project, Seoul 03722, South Korea; [Lee, In Hye] Ewha Womans Univ, Coll Nat Sci, Dept Life Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold
- 발행기관 KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000208635
- 본문언어 영어
- Published As https://doi.org/10.5483/BMBRep.2022-0211
초록/요약
Obesity increases the risk of mortality and morbidity because it results in hypertension, heart disease, and type 2 diabetes. Therefore, there is an urgent need for pharmacotherapeutic drugs to treat obesity. We performed a screening assay using natural products with anti-adipogenic properties in 3T3-L1 cells and determined that tschimganidine, a terpenoid from the Umbel-liferae family, inhibited adipogenesis. To evaluate the anti -obe-sity effects of tschimganidine in vivo. Mice were fed either a normal chow diet (NFD) or a high-fat chow diet (HFD) with or without tschimganidine for 12 weeks. Treatment with tschim-ganidine decreased lipid accumulation and adipogenesis, ac-companied by reduced expression of adipogenesis and lipid ac-cumulation-related factors. Tschimganidine significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and decreased that of AKT. Depletion of AMPK relieved the reduction in lipid accumulation resulting from tschimganidine treatment. Moreover, tschimganidine administration drastically reduced the weight and size of both gonadal white adipose tissue (WAT) and blood glucose levels in high-fat diet-induced obese mice. We suggest that tschimganidine is a potent anti -obesity agent, which impedes adipogenesis and improves glu-cose homeostasis. Tschimganidine can then be evaluated for clinical application as a therapeutic agent. [BMB Reports 2023; 56(4): 246-251]
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