The role of diuretic hormones (DHs) and their receptors in Drosophila
- 주제(키워드) DH31 , DH31 receptor , DH44 , DH44 receptors , Drosophila , Feeding , Fluid secretion , Nutrient sensing , Sleep , wake cycle
- 주제(기타) Biochemistry & Molecular Biology
- 설명문(일반) [Lee, Gahbien; Fang, Heejin; Oh, Yangkyun] Ewha Womans Univ, Coll Nat Sci, Dept Life Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000208751
- 본문언어 영어
- Published As https://doi.org/10.5483/BMBRep.2023-0021
- PubMed 36977606
초록/요약
Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory in-puts and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homo-logs of mammalian corticotropin-releasing factor (CRF) and cal-citonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their re-ceptors have multiple physiological roles, including the regula-tion of body-fluid secretion, sleep:wake cycle, internal nutrient -sensing, and CO2-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuro-endocrine systems. [BMB Reports 2023; 56(4): 209-215]
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