Fat mass index and airway hyperresponsiveness in Korean adults
- 주제(키워드) Asthma , airway hyperresponsiveness , body composition , fat mass , muscle mass , obesity
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Shim, Ji-Su; Kim, Min-Hye; Cho, Young-Joo] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Kim, Sun-Sin; Lee, So-Hee; Park, Heung-Woo] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Kim, Sun-Sin; Lee, So-Hee] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Seoul, South Korea; [Park, Heung-Woo] Seoul Natl Univ, Med Res Ctr, Inst Allergy & Clin Immunol, Seoul, South Korea; [Park, Heung-Woo] Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 TAYLOR & FRANCIS LTD
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000208861
- 본문언어 영어
- Published As https://doi.org/10.1080/00325481.2023.2188000
- PubMed 36879538
초록/요약
ObjectiveAirway hyperresponsiveness (AHR) is associated with asthma and obesity, which is defined as a high body mass index. Body mass mainly comprises fat mass (FM) and muscle mass (MM), which are independent of each other. We investigated the effect of changes in FM over time on the development of asymptomatic AHR in adults.MethodsThis long-term longitudinal study included adults who were underwent health checkups at the Seoul National University Hospital Gangnam Center. The participants underwent two methacholine bronchial provocation tests with a follow-up period (between the first and second tests) of more than 3 years and bioelectrical impedance analysis (BIA) at all visits. FM index (FMI; FM normalized for height) and MM index (MMI; MM normalized for height) were calculated using BIA.ResultsThe study included 328 adult participants (61 women and 267 men). The mean number of BIA measurements was 6.96 and the follow-up duration was 6.69 years. In total, 13 participants showed a positive conversion of AHR. Multivariate analysis indicated that a high rate of change in FMI ([g/m(2)]/year), not MMI, was significantly associated with the risk of AHR development (P = 0.037) after adjustment for age, sex, smoking status, and FEV1 predicted.ConclusionA rapid gain of FM over time may be a risk factor for developing AHR in adults. Prospective studies are needed to confirm our results and evaluate the role of FM reduction in preventing AHR development in obese adults.
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