Development of Inclined Applicators for Flattened Beam Intraoperative Radiotherapy
- 주제(키워드) inclined applicator , IORT , leakage dose , output calibration , uniformity
- 등재 SCIE, SCOPUS
- OA유형 All Open Access; Gold Open Access; Green Open Access
- 발행기관 Multidisciplinary Digital Publishing Institute (MDPI)
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000211527
- 본문언어 영어
- Published As https://doi.org/10.3390/app13169099
초록/요약
A 3D-printed applicator for intraoperative radiation therapy (IORT) using the INTRABEAM system has been introduced, designed to protect normal tissue, expand indications, and assess its effectiveness in various intraoperative settings. The study involved designing and creating inclined applicators at 0° and 45° angles, which were capable of producing flattened and unflattened beams and shielding non-target areas from radiation. The applicator was evaluated based on dose uniformity, percentage depth dose, leakage, and dose rate. The findings showed that the applicator provided a uniform beam at various depths (1.23 to 1.30 for the flattened beam and 1.25 to 1.32 for the unflattened beam) and effectively shielded against leakage, with no leakage dose measured at 1 mm from the surface. Additionally, the dose rates after 3 min of irradiation for flattened and unflattened beams were 51.0 and 52.9 cGy for 0° and 48.5 and 54.8 cGy for 45° applicators, respectively. This suggests that the applicator can efficiently deliver IORT while minimizing exposure to normal tissues, particularly in treating chest and abdominal lesions near or on critical organs. The applicator has undergone dose calibration and has moved forward to clinical application. © 2023 by the authors.
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