Disturbed insular functional connectivity and its clinical implication in patients with complex regional pain syndrome
- 주제(키워드) Complex regional pain syndrome , Insula , functional connectivity , Magnetic resonance imaging
- 주제(기타) Neuroimaging
- 설명문(일반) [Kim, Jinsol; Lee, Suji; Ha, Eunji; Hong, Haejin; Song, Yumi; Lee, Hyangwon; Oh, Sohyun; Lyoo, In Kyoon; Yoon, Sujung] Ewha Womans Univ, Ewha Brain Inst, Seoul, South Korea; [Namgung, Eun] Asan Inst Life Sci, Asan Med Ctr, Seoul, South Korea; [Song, Yumi; Lee, Hyangwon; Oh, Sohyun; Lyoo, In Kyoon; Yoon, Sujung] Ewha Womans Univ, Dept Brain & Cognit Sci, Seoul, South Korea; [Lyoo, In Kyoon] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Jeong, Hyeonseok] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Nucl Med, Seoul, South Korea; [Yoon, Sujung] Ewha Womans Univ, Ewha Brain Inst, 52 Ewhayeodaegil, Seoul 03760, South Korea; [Yoon, Sujung] Ewha Womans Univ, Dept Brain & Cognit Sci, 52 Ewhayeodaegil, Seoul 03760, South Korea; [Jeong, Hyeonseok] Catholic Univ Korea, Coll Med, Dept Nucl Med, Incheon St Marys Hosp, 56 Dongsu ro, Incheon 21431, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000211530
- 본문언어 영어
- Published As https://doi.org/10.1016/j.nicl.2023.103440
- PubMed 37224606
초록/요약
Background: Complex regional pain syndrome (CRPS) is characterized by continued amplification of pain intensity. Given the pivotal roles of the insula in the perception and interpretation of pain, we examined insular functional connectivity and its associations with clinical characteristics in patients with CRPS.Methods: Twenty-one patients with CRPS and 49 healthy controls underwent resting-state functional magnetic resonance imaging. The seed-to-seed functional connectivity analysis was performed for the bilateral insulae and cognitive control regions including the dorsal anterior cingulate cortex (dACC) and bilateral dorsolateral prefrontal cortex (DLPFC) between the two groups. Correlations between altered functional connectivity and clinical characteristics were assessed in CRPS patients.Results: CRPS patients exhibited lower functional connectivity within the bilateral anterior insulae, between the insular and cognitive control regions (the bilateral anterior/posterior insulae-dACC; the right posterior insula-left DLPFC), as compared with healthy controls at false discovery rate-corrected p < 0.05. In CRPS patients, pain severity was associated negatively with the left-right anterior insular functional connectivity (r = -0.49, p = 0.03), yet positively with the left anterior insula-dACC functional connectivity (r = 0.51, p = 0.02).Conclusions: CRPS patients showed lower functional connectivity both within the bilateral anterior insulae and between the insular and cognitive control regions. The current findings may suggest pivotal roles of the insula in dysfunctional pain processing of CRPS patients.
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