Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection
- 주제(키워드) Adenovirus vector , Influenza vaccine , Intramuscular administration , Intranasal administration , Lung CD8 T<sub>RM</sub>
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 All Open Access; Bronze Open Access
- 발행기관 Korean Association of Immunologists
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000211562
- 본문언어 영어
- Published As https://doi.org/10.4110/in.2023.23.e32
- PubMed 37670808
초록/요약
Most influenza vaccines currently in use target the highly variable hemagglutinin protein to induce neutralizing antibodies and therefore require yearly reformulation. T cell-based universal influenza vaccines focus on eliciting broadly cross-reactive T-cell responses, especially the tissue-resident memory T cell (TRM) population in the respiratory tract, providing superior protection to circulating memory T cells. This study demonstrated that intramuscular (i.m.) administration of the adenovirus-based vaccine expressing influenza virus nucleoprotein (rAd/NP) elicited weak CD8 TRM responses in the lungs and airways, and yielded poor protection against lethal influenza virus challenge. However, a novel “prime-and-deploy” strategy that combines i.m. vaccination of rAd/NP with subsequent intranasal administration of an empty adenovector induced strong NP-specific CD8+ TRM cells and provided complete protection against influenza virus challenge. Overall, our results demonstrate that this “prime-and-deploy” vaccination strategy is potentially applicable to the development of universal influenza vaccines. © 2023. The Korean Association of Immunologists.
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