Sex differences in the structural rich-club connectivity in patients with Alzheimer's disease
- 주제(키워드) sex differences , structural brain network , network analysis , rich-club organization , thalamus
- 주제(기타) Geriatrics & Gerontology; Neurosciences
- 설명문(일반) [Kim, Soo-Jong; Park, Yu Hyun; Jang, Hyemin; Kim, Jun Pyo; Seo, Sang Won] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; [Kim, Soo-Jong; Park, Yu Hyun; Jang, Hyemin; Kim, Jun Pyo] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea; [Kim, Soo-Jong; Park, Yu Hyun; Seo, Sang Won] Sungkyunkwan Univ, Dept Intelligent Precis Healthcare Convergence, Suwon, South Korea; [Kim, Soo-Jong; Park, Yu Hyun; Seo, Sang Won] Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea; [Bae, Youn Jung; Seong, Joon-Kyung] Korea Univ, Sch Biomed Engn, Seoul, South Korea; [Seo, Sang Won] Samsung Med Ctr, Alzheimers Dis Convergence Res Ctr, Seoul, South Korea; [Seo, Sang Won] Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, Seoul, South Korea; [Seong, Joon-Kyung] Korea Univ, Dept Artificial Intelligence, Seoul, South Korea; [Kim, Geon Ha] Ewha Womans Univ, Dept Neurol, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000211625
- 본문언어 영어
- Published As https://doi.org/10.3389/fnagi.2023.1209027
- PubMed 37771522
초록/요약
Background and objectivesAlzheimer's disease (AD) is more prevalent in women than in men; however, there is a discrepancy in research on sex differences in AD. The human brain is a large-scale network with hub regions forming a central core, the rich-club, which is vital to cognitive functions. However, it is unknown whether alterations in the rich-clubs in AD differ between men and women. We aimed to investigate sex differences in the rich-club organization in the brains of patients with AD.MethodsIn total, 260 cognitively unimpaired individuals with negative amyloid positron emission tomography (PET) scans, 281 with prodromal AD (mild cognitive impairment due to AD) and 285 with AD dementia who confirmed with positive amyloid PET scans participated in the study. We obtained high-resolution T1-weighted and diffusion tensor images and performed network analysis.ResultsWe observed sex differences in the rich-club and feeder connections in patients with AD, suggesting lower structural connectivity strength in women than in men. We observed a significant group-by-sex interaction in the feeder connections, particularly in the thalamus. In addition, the connectivity strength of the thalamus in the feeder connections was significantly correlated with general cognitive function in only men with prodromal AD and women with AD dementia.ConclusionOur findings provide important evidence for sex-specific alterations in the structural brain network related to AD.
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