Amyloid Fibers Increase Free Radicals of Synthetic Melanin
- 주제(키워드) cytoprotection , functional amyloids , melanins , radical scavenging , water remediation
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000211880
- 본문언어 영어
- Published As https://doi.org/10.1021/acsami.3c07909
- PubMed 37539960
초록/요약
Functional amyloid fibers are crucial in melanogenesis, but their roles are incompletely understood. In particular, their relationship with intrinsic spin characters of melanin remains unexplored. Here, we show that adding an amyloid scaffold greatly augments the spin density in synthetic melanin. It also brings about concurrent alterations in water dispersibility, bandgaps, and radical scavenging properties of the synthetic melanin, which facilitates its applications in solar water remediation and protection of human keratinocytes from UV irradiation. This work provides implications in the unrevealed role of functional amyloid in melanogenesis and in the origin of the superiority of natural melanin toward its synthetic variants in terms of the spin-related properties. © 2023 American Chemical Society.
more