Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction, and angina pectoris in Korean population
- 주제(키워드) Angina pectoris , Myocardial infarction , Myocardial ischemia , Proteinuria
- 주제(기타) Public, Environmental & Occupational Health
- 설명문(일반) [Park, Sung Keun; Jung, Ju Young] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Total Healthcare Ctr, Seoul, South Korea; [Kim, Min -Ho; Shin, Soonsu] Kyung Hee Univ, Grad Sch, Dept Prevent Med, Seoul, South Korea; [Kim, Min -Ho] Ewha Womans Univ, Seoul Hosp, Informatizat Dept, Seoul, South Korea; [Oh, Chang-Mo] Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea; [Ha, Eunhee] Ewha Womans Univ, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea; [Yang, Eun Hye; Lee, Hyo Choon] Kyung Hee Univ Hosp, Dept Occupat & Environm Med, Seoul, South Korea; [Hwang, Woo Yeon] Kyung Hee Univ Hosp Gangdong, Dept Obstet & Gynecol, Seoul, South Korea; [Lee, Sangho] Kyung Hee Univ, Med Ctr, Dept Anesthesiol & Pain Med, Seoul, South Korea; [Shin, So Youn] Kyung Hee Univ, Sch Med, Dept Radiol, Seoul, South Korea; [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, Seoul, South Korea; [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, 23 Kyungheedae Ro, Seoul 02447, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Gold Open Access
- 발행기관 KOREAN SOC EPIDEMIOLOGY
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213338
- 본문언어 영어
- Published As https://doi.org/10.4178/epih.e2023088
- PubMed 37817566
초록/요약
Objectives: Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease.Methods: The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative -> negative; resolved: proteinuria >= 1+ -> negative; incident: negative -> proteinuria >= 1+; persistent: proteinuria >= 1+ -> proteinuria >= 1+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris.Results: The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]).Conclusions: Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.
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