Differential Expression Patterns of Toll-like Receptors in COVID-19 Patients
- 주제(키워드) TLR , COVID-19 , SARS-CoV-2 , biomarkers
- 주제(기타) Biochemistry & Molecular Biology; Cell Biology
- 설명문(일반) [Lee, Nawon; Ko, Ryeojin; Lee, Soo Young] Ewha Womans Univ, Dept Life Sci, Seoul 03760, South Korea; [Ko, Ryeojin; Lee, Soo Young] Ewha Womans Univ, Res Ctr Cellular Homeostasis, Seoul 03760, South Korea; [Ko, Ryeojin; Lee, Soo Young] Ewha Womans Univ, Multitasking Macrophage Res Ctr, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Gold Open Access
- 발행기관 IMR PRESS
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213368
- 본문언어 영어
- Published As https://doi.org/10.31083/j.fbl2811307
- PubMed 38062845
초록/요약
Since Toll-like receptors (TLRs) recognize the earliest signs of infection or cell damage, they play fundamental roles in innate immunity. This review summarizes the numerous studies on the expression of TLRs in patients with Coronavirus disease 2019 (COVID-19). We show that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can stimulate at least six of the ten TLRs in humans and that this can shape the severity of COVID-19. Specifically, TLR2, TLR4, and TLR9 appear to play pathogenic roles while TLR3, TLR7, and TLR8 may be protective. Most have mutations that could partly explain the susceptibility phenotypes of COVID19. Further understanding the roles of TLRs in COVID-19 immunopathogenesis could reveal prognostic biomarkers and help drive the
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