Turning an FDA-approved therapeutic into an AIEgen for imaging live bacteria and for bacterial detection
- 주제(키워드) Aggregation-Induced Emission , Antimicrobials , Fluorescence imaging and Theranostics
- 등재 SCOPUS
- 발행기관 John Wiley and Sons Inc
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213402
- 본문언어 영어
- Published As https://doi.org/10.1002/agt2.47
초록/요약
Aggregation Induced Emission (AIE) is an attractive, fluorescent-based phenomenon that can be used to design fluorescent imaging agents and fluorescent sensors. In this highlight, we discuss a recently reported study that identifies the chemical scaffold of an FDA-approved therapeutic (deferasirox) as a molecule with AIE-like properties (AIEgen). Utilizing its therapeutic efficacy for bacterial biofilms, deferasirox-derivatives were shown able to treat and image bacteria biofilms and detect a bacterial biomarker. This demonstrates the potential of AIE for drug design as this allows the simultaneous ability to image the therapeutic's location and mode of action. © 2021 The Authors. Aggregate published by South China University of Technology; AIE Institute and John Wiley & Sons Australia, Ltd.
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