The Effect of Vanishing Twin on First- and Second-Trimester Maternal Serum Markers and Nuchal Translucency: A Multicenter Prospective Cohort Study
- 주제(키워드) Vanishing Twin , First-and Second-Trimester Maternal Serum Markers , PAPP-A , AFP , hCG , uE3
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Lee, Se Jin; Bae, Ji Hye; Park, Chan-Wook; Park, Joong Shin; Jun, Jong Kwan; Lee, Seung Mi] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; [Han, You Jung; Kim, Soo Hyun; Cha, Dong Hyun] CHA Univ, CHA Gangnam Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; [Kim, Minhyoung] Mizmedi Hosp, Dept Obstet & Gynecol, Seoul, South Korea; [Shim, Jae-Yoon; Lee, Mi-Young] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; [Oh, Soo-young] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; [Lee, Joonho] Yonsei Univ, Coll Med, Yonsei Univ Hlth Syst, Dept Obstet & Gynecol,Inst Womens Life Med Sci, Seoul, South Korea; [Cho, Geum Joon] Korea Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; [Kwon, Han-Sung] Konkuk Univ, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; [Kim, Byoung Jae] Seoul Natl Univ, Boramae Med Ctr, Dept Obstet & Gynecol, Seoul Metropolitan Govt, Seoul, South Korea; [Park, Mi Hye] Ewha Womans Univ, Dept Obstet & Gynecol, Seoul, South Korea; [Cho, Hee Young; Ryu, Hyun Mee] CHA Univ, Bundang CHA Hosp, Dept Obstet & Gynecol, Sch Med, Seongnam, South Korea; [Ko, Hyun Sun] Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; [Oh, Sohee] Seoul Natl Univ, Med Res Collaborating Ctr, Boramae Med Ctr, Seoul Metropolitan Govt, Seoul, South Korea; [Lee, Se Jin; Lee, Da Rae] Kangwon Natl Univ, Dept Obstet & Gynecol, Kangwon Natl Univ Hosp, Sch Med, Chunchon, South Korea; [Lee, Seung Mi] Seoul Natl Univ Hosp, Dept Obstet & Gynecol, Seoul, South Korea; [Lee, Seung Mi] Seoul Natl Univ Hosp, Innovat Med Technol Res Inst, Seoul, South Korea; [Lee, Seung Mi] Seoul Natl Univ Hosp, Dept Obstet & Gynecol, 101 Daehak Ro, Seoul 03080, South Korea; [Ryu, Hyun Mee] CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Obstet & Gynecol, 59 Yatap Ro, Seongnam 13496, South Korea; [Lee, Se Jin] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Dept Obstet & Gynecol, Sch Med, Chunchon, South Korea; [Cho, Hee Young] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Gold Open Access; Green Published
- 발행기관 KOREAN ACAD MEDICAL SCIENCES
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213418
- 본문언어 영어
- Published As https://doi.org/10.3346/jkms.2023.38.e300
- PubMed 37750371
초록/요약
Background: The purpose of this study was to evaluate the effect of vanishing twin (VT) on maternal serum marker concentrations and nuchal translucency (NT).Methods: This is a secondary analysis of a multicenter prospective cohort study in 12 institutions. Serum concentrations of pregnancy-associated plasma protein-A in the first trimester and alpha-fetoprotein (AFP), total human chorionic gonadotrophin, unconjugated estriol, and inhibin A in the second trimester were measured, and NT was measured between 10 and 14 weeks of gestation.Results: Among 6,793 pregnant women, 5,381 women were measured for serum markers in the first or second trimester, including 65 cases in the VT group and 5,316 cases in the normal singleton group. The cases in the VT group had a higher median multiple of the median value of AFP and inhibin A than the normal singleton group. The values of other serum markers and NT were not different between the two groups. After the permutation test with adjustment, AFP and inhibin A remained significant differences. The frequency of abnormally increased AFP was also higher in the VT group than in the normal singleton group.Conclusion: VT can be considered as an adjustment factor for risk assessment in the second -trimester serum screening test.
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