Angiotensin-converting enzyme insertion/deletion gene polymorphism and the progression of cerebral microbleeds
- 주제(키워드) cerebral microbleeds (CMB) , cerebral small vessel disease (CSVD) , angiotensin-converting enzyme , polymorphism , insertion/deletion polymorphism
- 주제(기타) Clinical Neurology; Neurosciences
- 설명문(일반) [Yoon, Cindy W.; Kim, Jonguk; Choi, Seong Hye] Inha Univ, Sch Med, Dept Neurol, Incheon, South Korea; [Suh, Young Ju] Inha Univ, Sch Med, Dept Biomed Sci, Incheon, South Korea; [Kim, Byeong C.] Chonnam Natl Univ, Med Sch, Dept Neurol, Gwangju, South Korea; [Youn, Young Chul] Chung Ang Univ, Coll Med, Dept Neurol, Seoul, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; [Han, Hyun Jeong] Hanyang Univ, Coll Med, Myongji Hosp, Dept Neurol, Goyang, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Gold Open Access; Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213472
- 본문언어 영어
- Published As https://doi.org/10.3389/fneur.2023.1230141
- PubMed 37900609
초록/요약
Background and purposeThe angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism has been studied as a genetic candidate for cerebral small vessel disease (CSVD). However, no previous study has evaluated the relationship between the ACE I/D polymorphism and cerebral microbleed (CMB), an important CSVD marker. We evaluated the association between ACE I/D polymorphisms and 2-year changes in CMBs.MethodsThe CHALLENGE (Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes) database was analyzed. Of 256 subjects, 186 participants who underwent a 2-year follow-up brain scan and ACE genotyping were included. Our analysis was conducted by dividing the ACE genotype into two groups (DD vs. ID/II) under the assumption of the recessive effects of the D allele. A linear mixed-effect model was used to compare the 2-year changes in the number of CMBs between the DD and combined ID/II genotypes.ResultsAmong 186 patients included in this study, 24 (12.9%) had the DD genotype, 91 (48.9%) had the ID genotype, and 71 (38.2%) had the II genotype. Baseline clinical characteristics and cerebral small vessel disease markers were not different between the two groups (DD vs. ID/II) except for the prevalence of hypertension (DD 66.7% vs. ID/II 84.6%; p = 0.04). A multivariate linear mixed-effects model showed that the DD carriers had a greater increase in total CMB counts than the ID/II carriers after adjusting for the baseline number of CMBs, age, sex, and hypertension (estimated mean of difference [standard error (SE)] = 1.33 [0.61]; p = 0.03). When we performed an analysis of cases divided into deep and lobar CMBs, only lobar CMBs were significantly different between the two groups (estimated mean of difference [SE] = 0.94 [0.42]; p = 0.02).ConclusionThe progression of CMBs over 2 years was greater in the ACE DD carriers compared with the combined II/ID carriers. The results of our study indicate a possible association between the ACE I/D polymorphism and CMB. A study with a larger sample size is needed to confirm this association.
more