Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer's disease: a randomized controlled trial
- 주제(키워드) Alzheimer's disease , dementia , mild cognitive impairment , prevention , multidomain intervention , nutritional supplements , gut microbiome
- 주제(기타) Geriatrics & Gerontology; Neurosciences
- 설명문(일반) [Lee, Eun Hye; Kim, Geon Ha; Jeong, Jee Hyang] Ewha Womans Univ, Dept Neurol, Sch Med, Seoul, South Korea; [Lee, Eun Hye; Jeong, Jee Hyang] Ewha Womans Univ, Dept Neurol, Seoul Hosp, Seoul, South Korea; [Kim, Geon Ha] Ewha Womans Univ, Dept Neurol, Mokdong Hosp, Seoul, South Korea; [Park, Hee Kyung] UCL, Dept Mental Hlth Care Older People, Div Psychiat, London, England; [Kang, Hae Jin; Park, Yoo Kyoung] Kyung Hee Univ, Dept Med Nutr, AgeTech Serv Convergence Major, Yongin, South Korea; [Lee, Hye Ah] Ewha Womans Univ, Clin Trial Ctr, Mokdong Hosp, Seoul, South Korea; [Hong, Chang Hyung] Ajou Univ, Dept Psychiat, Sch Med, Suwon, South Korea; [Moon, So Young] Ajou Univ, Dept Neurol, Sch Med, Suwon, South Korea; [Kang, Woorim; Oh, Hyun-Seok] CJ Biosci Inc, Seoul, South Korea; [Yoon, Hai-Jeon] Ewha Womans Univ, Dept Nucl Med, Sch Med, Seoul, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Coll Med, Incheon, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Gold Open Access; Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213474
- 본문언어 영어
- Published As https://doi.org/10.3389/fnagi.2023.1266955
- PubMed 38020771
초록/요약
Background: The SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN) is a part of the World-Wide Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (WW-FINGERS) network. This study aimed to demonstrate the effects of the SUPERBRAIN-based multidomain intervention with nutritional supplements in amyloid positive emission tomography (PET) proven early symptomatic Alzheimer's disease patients.Methods: Forty-six participants who were diagnosed with mild cognitive impairment or mild dementia and were positive in the amyloid PET study randomized into three groups: group A, the multidomain intervention with nutritional supplements; group B, nutritional supplements only; and a control group. The primary outcome was a change in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total scale index score after an 8-week intervention. Secondary outcomes, including gut microbiome data, were also analyzed.Results: The RBANS total scale index score improved significantly in group A compared with group B (p < 0.032) and compared with the control group (p < 0.001). After intervention, beta diversity of the gut microbiome between group A and the control group increased, and patients in group A were more enriched with Bifidobacterium.Conclusion: SUPERBRAIN-based multidomain intervention with nutritional supplements improves cognition and gut microbiota in patients with early symptomatic Alzheimer's disease who were amyloid-positive by PET.
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