Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Gold Open Access; Green Open Access
- 발행기관 Springer Nature
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213590
- 본문언어 영어
- Published As https://doi.org/10.1038/s12276-023-01086-x
- PubMed 37779140
초록/요약
Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles. © 2023, The Author(s).
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