Roles of Protein Post-Translational Modifications During Adipocyte Senescence
- 주제(키워드) Adipocyte , Senescence , Post-translational modification , Metabolic disease , Metabolic homeostasis
- 주제(기타) Biochemistry & Molecular Biology; Biology
- 설명문(일반) [Hwang, Min-Seon; Chun, Kyung-Hee] Yonsei Univ, Grad Sch Med Sci, Dept Biochem & Mol Biol, Brain Korea Project 21,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; [Park, Jingyeong; Ham, Yunha; Lee, In Hye] Ewha Womans Univ, Coll Nat Sci, Dept Life Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Chun, Kyung-Hee] Yonsei Univ, Dept Biochem & Mol Biol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published; Gold Open Access
- 발행기관 IVYSPRING INT PUBL
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213609
- 본문언어 영어
- Published As https://doi.org/10.7150/ijbs.86404
- PubMed 37928271
초록/요약
Adipocytes are adipose tissues that supply energy to the body through lipids. The two main types of adipocytes comprise white adipocytes (WAT) that store energy, and brown adipocytes (BAT), which generate heat by burning stored fat (thermogenesis). Emerging evidence indicates that dysregulated adipocyte senescence may disrupt metabolic homeostasis, leading to various diseases and aging. Adipocytes undergo senescence via irreversible cell-cycle arrest in response to DNA damage, oxidative stress, telomere dysfunction, or adipocyte over-expansion upon chronic lipid accumulation. The amount of detectable BAT decreases with age. Activation of cell cycle regulators and dysregulation of adipogenesis-regulating factors may constitute a molecular mechanism that accelerates adipocyte senescence. To better understand the regulation of adipocyte senescence, the effects of post-translational modifications (PTMs), is essential for clarifying the activity and stability of these proteins. PTMs are covalent enzymatic protein modifications introduced following protein biosynthesis, such as phosphorylation, acetylation, ubiquitination, or glycosylation. Determining the contribution of PTMs to adipocyte senescence may identify new therapeutic targets for the regulation of adipocyte senescence. In this review, we discuss a conceptual case in which PTMs regulate adipocyte senescence and explain the mechanisms underlying protein regulation, which may lead to the development of effective strategies to combat metabolic diseases.
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