Comparative Bleeding Risk in Patients with Atrial Fibrillation with Cancer versus Without Cancer from Nationwide Prospective Cohort CODE-AF Registry
- 주제(키워드) Non-valvular atrial fibrillation , Anti-coagulation , Composite events
- 주제(기타) Cardiac & Cardiovascular Systems
- 설명문(일반) [Kang, Ki-Woon; Shin, Seung Young] Chung Ang Univ Hosp, Div Cardiol, Seoul, South Korea; [Shin, David] Univ Calif Los Angeles, Div Hematol & Oncol, Los Angeles, CA USA; [Kim, Jun; Cha, Myung-Jin] Univ Ulsan, Coll Med, Heart Inst, Asan Med Ctr, Seoul, South Korea; [Choi, Eu-Keun] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Lee, Jung-Myung; Kim, Jin-Bae] Kyung Hee Univ, Kyung Hee Univ Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea; [Park, Junbeom] Ewha Womans Univ, Sch Med, Dept Pathol, Seoul, South Korea; [Park, Jin-Kyu] Hanyang Univ, Seoul Hosp, Dept Cardiol, Seoul, South Korea; [Kim, Tae-Hoon; Uhm, Jae -Sun; Joung, Boyoung] Yonsei Univ, Severance Cardiovasc Hosp, Dept Internal Med, Div Cardiol,Coll Med, Seoul, South Korea; [Shim, Jaemin] Korea Univ, Med Ctr, Dept Internal Med, Div Cardiol, Seoul, South Korea; [Lee, Young Soo] Daegu Catholic Univ, Med Ctr, Dept Internal Med, Div Cardiol, Daegu, South Korea; [Park, Hyung Wook] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Cardiol, Gwangju, South Korea; [Kim, Changsoo] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Kang, Ki-Woon] Chung Ang Univ Hosp, Dept Cardiol, 102 Heukseok Ro, Seoul 06973, South Korea; [Joung, Boyoung] Yonsei Univ, Coll Med, Severance Hosp, Div Cardiol,Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Gold Open Access
- 발행기관 INT HEART JOURNAL ASSOC
- 발행년도 2023
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000213638
- 본문언어 영어
- Published As https://doi.org/10.1536/ihj.22-507
- PubMed 37704413
초록/요약
Comparison of the bleeding risk for long-term oral anticoagulation (OAC) in patients with nonvalvular atrial fibrillation (AF) with and without cancers has been inconsistent. This study aimed to clarify the differences in the bleeding risk in patients with AF with cancers and those without cancers during the long-term The CODE-AF prospective registry enrolled 5,902 consecutive patients treated for AF at 10 tertiary referral centers in Korea. Of the enrolled patients, 464 (7.8%) were diagnosed with cancers and were followed for all stroke and bleeding events (net composite events). The age, CHA2DS2-VASC, and HAS-BLED scores were similar between AF patients with and without cancers. Male population greatly comprised patients with AF with cancers. They were equally prescribed with direct OAC compared to those without cancers. The incidence rate for clinically relevant nonmajor (CRNM) bleeding events was higher in the patients with AF with cancers than in those without cancers (4.4 per 100 person-years versus 2.8 per 100 person-years, P = 0.023), and net composite events were also more frequent in patients with AF with cancers than in those without cancers (6.4 per 100 person-years versus 4.0 per 100 person-years, P = 0.004). Patients with AF with cancers showed a significantly higher rate of CRNM bleeding (hazard ratio [HR] 1.54, confidence interval [CI] 1.05-2.25, P = 0.002) than those without cancers. Based on the AF cohort, AF with cancers could face a significantly higher risk for CRNM bleeding events in the long-term OAC than those without cancers.
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